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Index > Protein center > Vdac1(Gene name) > Rat
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  • Vdac1 (Gene name),
  • Voltage-dependent anion-selective channel protein 1 (Protein name ),  VDAC1_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    Vdac1;
    Protein name:
    Voltage-dependent anion-selective channel protein 1(VDAC-1;rVDAC1);
    Alternative:
    Outer mitochondrial membrane protein porin 1;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Interacts with hexokinases (By similarity). Interacts with BCL2L1.
    Function:
    Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
    Subcellular Location:
    Mitochondrion outer membrane Cell membrane
    Protein Attributes:
    Sequence length:
    283
    Sequence:
    50:
    MAVPPTYADL | GKSARDVFTK | GYGFGLIKLD | LKTKSENGLE | FTSSGSANTE | 
    100:
    TTKVNGSLET | KYRWTEYGLT | FTEKWNTDNT | LGTEITVEDQ | LARGLKLTFD | 
    150:
    SSFSPNTGKK | NAKIKTGYKR | EHINLGCDVD | FDIAGPSIRG | ALVLGYEGWL | 
    200:
    AGYQMNFETS | KSRVTQSNFA | VGYKTDEFQL | HTNVNDGTEF | GGSIYQKVNK | 
    250:
    KLETAVNLAW | TAGNSNTRFG | IAAKYQVDPD | ACFSAKVNNS | SLIGLGYTQT | 
    283:
    LKPGIKLTLS | ALLDGKNVNA | GGHKLGLGLE | FQA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Rat VDAC-1
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    CLIA Kit for Rat VDAC-1
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    96T
    CLIA Kit for Rat VDAC-1
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    U12942p
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Rat VDAC-1
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    CLIA Kit for Rat VDAC-1
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    Packing:
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    Polyclonal Antibody for Rat VDAC-1
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    Polyclonal Antibody for Rat VDAC-1
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    Packing:
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    Monoclonal Antibody for Rat VDAC-1
    Monoclonal Antibody for Rat VDAC-1
    Monoclonal Antibody for Rat VDAC-1
    Monoclonal Antibody for Rat VDAC-1
    Monoclonal Antibody for Rat VDAC-1
    Monoclonal Antibody for Rat VDAC-1
    Protein for Rat VDAC-1
    Protein for Rat VDAC-1
    Protein for Rat VDAC-1
    Protein for Rat VDAC-1
    Protein for Rat VDAC-1
    Protein for Rat VDAC-1

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    References
    1. 1.
      "Characterization of rat porin isoforms: cloning of a cardiac type-3 variant encoding an additional methionine at its putative N-terminal region."
      Anflous K. , Blondel O. , Bernard A. , Khrestchatisky M. , Ventura-Clapier R.
      Biochim. Biophys. Acta1399:47-50(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Heart.
    2. 2.
      "Characterization of porin isoforms expressed in tumor cells."
      Shinohara Y. , Ishida T. , Hino M. , Yamazaki N. , Baba Y. , Terada H.
      Eur. J. Biochem.267:6067-6073(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
      tissue: Ascitic tumor.
    3. 3.
      "Ion channels in the lens."
      Rae J.L.
      Submitted (2000-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Sprague-Dawley.
      tissue: Lens.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
      tissue: Embryonic brain.
      tissue: Heart.
      tissue: Ovary.
      tissue: Pituitary.
      tissue: Placenta.
    5. 5.
      "Post-translational modifications of rat liver mitochondrial outer membrane proteins identified by mass spectrometry."
      Distler A.M. , Kerner J. , Hoppel C.L.
      Biochim. Biophys. Acta1774:628-636(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-14 AND 135-138;ACETYLATION AT ALA-2;PHOSPHORYLATION AT SER-13 AND SER-137;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Liver.
    6. 6.
      Lubec G. , Chen W.-Q. , Afjehi-Sadat L. , Kang S.U.
      Submitted (2007-07) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-28; 33-53; 64-74; 75-93; 97-109; 121-139; 164-197; 201-218 AND 225-266;IDENTIFICATION BY MASS SPECTROMETRY
      strain: Sprague-Dawley.
      tissue: Brain.
      tissue: Hippocampus.
      tissue: Spinal cord.
    7. 7.
      "Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore."
      Crompton M. , Virji S. , Ward J.M.
      Eur. J. Biochem.258:729-735(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPIF
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